Measuring & Inducing Neural Activity Using Extracellular Fields I: Inverse systems approach

This project considers the problem of trying to selectively sense and induce activity in individual neurons within a network in a living organism, using a small array of electrodes placed some distance away. We consider a variety of approaches to relate neural behavior to the potential or current at the electrode array. Then we perform a simulation using the simple linear model with uniform conductivity, and demonstrate the ability to resolve axons in the transverse direction. We also demonstrate the use of this same approach to estimate a current at the electrode array to achieve, as best possible, a desired potential difference within the neural tissue.